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UNICEF's mission is to help very child thrive, all over the world. Over eight decades, it has built an unprecedented global support system for the world’s children. UNICEF relentlessly works day in and day out to deliver the essentials that give every child an equitable chance in life: health care and immunizations, safe water and sanitation, nutrition, education, emergency relief and more. UNICEF USA advances the global mission of UNICEF by rallying the American public to support the world’s most vulnerable children. Through advocacy, education and fundraising in the United States. The organization's Impact Fund for Children provides opportunities for social impact investors seeking to make a difference in the survival and development of children.

Founded in 1947, Dana-Farber Cancer Institute is committed to providing expert, compassionate care to children and adults with cancer, while advancing the understanding, treatment, cure, and prevention of cancer and related diseases. As an affiliate of Harvard Medical School and a Comprehensive Cancer Center designated by the National Cancer Institute, the Institute also provides training for new generations of physicians and scientists, designs programs that promote public health particularly among high-risk and underserved populations and disseminates innovative patient therapies and scientific discoveries in Boston, across the United States and throughout the world.

Established in 1985, The ALS Association is dedicated to leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support. The Association builds hope and enhances the quality of life while aggressively searching for new treatments and a cure, through global research, providing assistance for people with ALS through a nationwide network of chapters, coordinating multidisciplinary care through certified clinical care centers, and fostering government partnerships.

The Cystic Fibrosis Foundation's mission is to find a cure for cystic fibrosis (CF) and to improve the quality of life for people living with the disease. We accomplish this by funding life-saving research and working to provide access to quality care and effective therapies for people with CF. Our work has contributed to doubling the life expectancy for people with CF beyond the age of 18, and increasing the availability of nearly every CF drug through the Foundation's support.

The American Foundation for Suicide Prevention is dedicated to saving lives and bringing hope to those affected by suicide. AFSP creates a culture that’s smart about mental health through education and community programs, develops suicide prevention through research and advocacy, and provides support for those affected by suicide. AFSP has local chapters in all 50 states with programs and events nationwide.

To mobilize the resources of the entertainment industry to raise funds to provide grants to AIDS service organizations and promote awareness of HIV/AIDS issues.

We create hope and build healthier futures. Children's Hospital Los Angeles is a nonprofit organization that depends on your generous donations to heal children in an environment that lets them thrive. Each year, more than 107,000 sick children come to the hospital for care. Support from the community helps pay for the breakthrough therapies and treatments that save young lives each year. As a leading academic children’s hospital, we fulfill our mission by: Caring for children, adolescents, young adults, families and each other, advancing knowledge, preparing future generations, and building our financial strength.

Race to Erase MS is dedicated to the treatment and ultimate cure of Multiple Sclerosis. Funding research is the core focus of the Foundation and all funds raised support our Center Without Walls program, a selected network of the nation's top MS research centers. This nationwide collaboration of physicians and scientists are on the cutting-edge of innovative research programs, working as a team on therapeutic approaches to eradicate MS. In addition to combating MS through research in a clinical environment, we hope to increase awareness by educating the public about this mystifying disease.

charity: water is a non-profit organization bringing clean and safe drinking water to people in developing nations. We inspire giving and empower others to fundraise for sustainable water solutions. We use local partners on the ground to build and implement the projects. Then, we prove every single project funded, using GPS coordinates, photos and stories from the field. We have funded 91, 414 water projects, aimed to serve 14, 762, 215 people in 29 countries. We believe that sustainable work is locally-led. Along with implementing community-owned water projects, our local partners help facilitate comprehensive water, sanitation, and hygiene (WASH) programming to protect everyone’s long-term health.