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The Huntington's Disease Society of America is the premier nonprofit organization dedicated to improving the lives of everyone affected by Huntington’s disease. From community services and education to advocacy and research, HDSA is the world’s leader in providing help for today and hope for tomorrow for people with Huntington’s disease and their families. HDSA's network of chapters, affiliates, HDSA Centers of Excellence, social workers and support groups provides a seamless connection for help, education and outreach to HD families and health care professionals across the United States.

Project C.U.R.E. was founded in 1987 to help bridge staggering health resource gaps in the developing world by matching medical supplies and modern equipment with facilities in need to empower doctors and nurses with the tools they need to treat disease, deliver vaccines, perform life-changing surgeries and ensure safe childbirth. Project C.U.R.E. operates distribution centers in Colorado, Tennessee, Texas and Arizona and receives donations of supplies and specialized equipment from hundreds of U.S. hospitals and medical manufacturers. Thanks to the dedication of thousands of volunteers nationwide, two to three cargo containers of life-saving aid leave Project C.U.R.E.’s warehouses every week. In addition, Project C.U.R.E. sends volunteer medical teams to underserved facilities abroad to provide free care and train local healthcare staff. Today, Project C.U.R.E. is the world’s largest distributor of medical donations to resource-limited communities across the globe, touching the lives of patients, families and children in 130 countries.

Alex’s Lemonade Stand Foundation (ALSF) is changing the lives of children with cancer by funding impactful research, raising awareness, supporting families and empowering everyone to help cure childhood cancer. When Alex, who was diagnosed with childhood cancer just before her first birthday, was 4, she told her parents she wanted to set up a front yard lemonade stand. Her plan: to give the money to doctors to help them find a cure. Her first “Alex’s Lemonade Stand,” held with the help of her older brother Patrick, raised an astonishing $2,000 in one day. While bravely fighting her own cancer, Alex continued to set up lemonade stands every year. As news spread of the remarkable girl so dedicated to helping other sick children, people everywhere were inspired to start their own lemonade stands — donating the proceeds to her cause. In 2004 when Alex passed away at the age of 8 — her stand and inspiration had raised more than $1 million towards finding a cure for the disease that took her life. Alex’s Lemonade Stand Foundation (ALSF) was started by her parents in 2005 to continue the work that Alex began. Our mission is simple: to change the lives of children with cancer through funding impactful research, raising awareness, supporting families and empowering everyone to help cure childhood cancer. Since Alex set up her first lemonade stand in 2000 — truly exemplifying the saying “When life hands you lemons, make lemonade” — we have raised more than $250 million. That money has helped to: - Fund more than 1,000 cutting-edge research projects at nearly 150 institutions. - Create a Travel For Care program to help support families of children receiving treatment and develop resources, such as our SuperSibs program to help people everywhere affected by childhood cancer. Alex’s Lemonade Stand Foundation is the living embodiment of Alex’s spirit of determination and hope. Like Alex, we believe that every person can make a difference. Together, we can bring about a cure. Please join us in “making lemons into lemonade” today!

Smile Train is an international children’s charity with a sustainable approach to a single, solvable problem: cleft lip and palate. Millions of children in developing countries with unrepaired clefts live in shame, but more importantly, have difficulty eating, breathing and speaking. Cleft repair surgery is simple, and the transformation is immediate. Our sustainable model provides training and funding to empower local doctors in 85+ developing countries to provide 100%-free cleft repair surgery in their communities. We use the “teach a man to fish” model focusing on training local doctors to perform cleft repairs in their communities. Those doctors then go on to train other doctors creating a long-term, sustainable system. Patients see their smile for the first time, parents cry tears of joy, lives and communities are changed forever. As a result of our efficiency and with the support of our donors and partners around the world, Smile Train has transformed the lives of more than one million children by giving them the power of a smile -- that's roughly 350 surgeries a day and 128,000+ every year.  

The Ruth Ellis Center (REC), incorporated in 1999, is a youth social services agency with a mission “to provide short-term and long-term residential safe space and support services for runaway, homeless, and at-risk lesbian, gay, bi-attractional, transgender and questioning (LGBTQ) youth.” As LGBTQ youth continue to be disproportionately affected by homelessness, the Ruth Ellis Center remains dedicated to ensuring that these vulnerable youth and young adults receive the services and inherent protections available to all citizens. While the Center emphasizes serving LGBTQ youth who are often ostracized, shamed, and denied services by other agencies, no youth, regardless of gender identity or sexual orientation is turned away or denied services

The National Pediatric Cancer Foundation (NPCF) is a nonprofit organization dedicated to funding and developing novel research and clinical trials to find less toxic, more effective treatments for childhood cancer. Our purpose is to reduce the side effects of current treatments, improve survival rates, and ultimately eliminate childhood cancer. NPCF is a nonprofit organization under section 501(c)(3) of the Internal Revenue Code. At the National Pediatric Cancer Foundation, we are aggressively pursuing measurable change in how pediatric cancer research is approached and funded through our collaborative research consortium, the Sunshine Project. The Sunshine Project’s one-of-a-kind research model focuses on translational studies and phase 0, 1, and 2 clinical trials that address a multitude of different pediatric cancers. Our innovative approach capitalizes on the strengths of researchers from various scientific fields throughout the country, streamlining the protocol development process to deliver more personalized medicine to children with cancer. This utilization of scientific and philanthropic partnerships allows us to fast-track potential new therapies with less toxicity into clinical trials. The treatment options currently being discovered bring great promise for children who have not experienced positive results under the standard treatment protocol.

ASK is a 501(c)(3) organization founded in 1975 by a small group of parents whose children had cancer. They came together to provide mutual support, search for answers, and deal with the devastating news no parent ever wants to hear: “Your child has cancer.” With 1-2 children diagnosed per week in Central VA, your donation will be a great help to our small, local nonprofit dedicated to making life better for children with cancer. Your support will help to provide emotional, social, financial and educational care to children with cancer who are treated at the Children’s Hospital of Richmond at VCU, the only treatment facility for childhood cancer in Central Virginia. ASK provides children, siblings, and caregivers with support from the moment of diagnosis through treatment to survivorship or bereavement.

The Los Angeles LGBT Center (formerly L.A. Gay and Lesbian Center) exists to: EMPOWER people to lead full and rewarding lives without limits based on sexual orientation and gender identity, by providing the highest quality educational, cultural, and wellness programs to residents of Los Angeles County; HEAL the damage caused by discrimination based on sexual orientation and gender identity, by providing the highest quality health and social services to residents of Los Angeles County in need; ADVOCATE full access and equality for all people regardless of sexual orientation or gender identity, by promoting our communities' needs at local, state, and national levels; and LEAD through example, by living our values, sharing our expertise, and celebrating the full diversity of our lives, families, and communities.

The Community Hospice is a non-profit 501(c)(3) organization, accredited by the Community Health Accreditation Program. We are part of St. Peter's Health Partners, and are privileged to work with every hospital in the region to provide hospice services. We serve more than 4,300 seriously ill patients and their families a year. The elderly, terminally ill and dying are among the most vulnerable people in our society. Incredible advances in medical care and social services haven’t ended the tragedy of people dying alone or in pain. Meeting that need is our mission: The Community Hospice serves seriously ill people and their families during the process of dying and grieving. We enhance quality of life with comprehensive, compassionate services that respect the dignity of those we serve. And we offer that help and comfort in eight counties in upstate New York: Albany, Schenectady, Rensselaer, Saratoga, Columbia, Greene, Montgomery and Washington.

The Audre Lorde Project is a Lesbian, Gay, Bisexual, Two Spirit, Trans and Gender Non Conforming People of Color center for community organizing, focusing on the New York City area. Through mobilization, education and capacity-building, we work for community wellness and progressive social and economic justice. Committed to struggling across differences, we seek to responsibly reflect, represent and serve our various communities.

Safehouse Progressive Alliance for Nonviolence (SPAN) is a human rights organization committed to ending violence against adults, youth and children through support, advocacy, education and community organizing. Our vision is a just and equitable world for all individuals  and their their families.

CTF was born from the idea that the world would be a better place if we were all given the opportunity to give back. Established by a group of water women, we feel it is our calling to help others by teaming up with local organizations globally to raise awareness and address social, environmental, health and safety concerns in the places we visit. We aim to bridge the gap between the traveler and our projects enabling travelers to add a life-changing experience to their journeys and add purpose to travel.