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Smile Train is an international children’s charity with a sustainable approach to a single, solvable problem: cleft lip and palate. Millions of children in developing countries with unrepaired clefts live in shame, but more importantly, have difficulty eating, breathing and speaking. Cleft repair surgery is simple, and the transformation is immediate. Our sustainable model provides training and funding to empower local doctors in 85+ developing countries to provide 100%-free cleft repair surgery in their communities. We use the “teach a man to fish” model focusing on training local doctors to perform cleft repairs in their communities. Those doctors then go on to train other doctors creating a long-term, sustainable system. Patients see their smile for the first time, parents cry tears of joy, lives and communities are changed forever. As a result of our efficiency and with the support of our donors and partners around the world, Smile Train has transformed the lives of more than one million children by giving them the power of a smile -- that's roughly 350 surgeries a day and 128,000+ every year.  

With the success of the Salk vaccine in the mid 1950s, the March of Dimes turned its focus on birth defects, low birth weight and infant death. Over the past 75 years, March of Dimes' cutting edge research and innovative programs have saved millions of babies from death or disability. We are committed to educating medical professionals and the public, supporting research, providing comfort and support to families in NICUs, and advocating for moms and babies. All mothers and babies deserve access to the tools they need for the success of their families, so that the future is brighter for all. Every Mom. Every Baby.

Our mission is to find a effective treatments and ultimately a cure for fragile X syndrome, the most common inherited cause of autism. We directly fund research grants and fellowships at top universities around the world. FRAXA was founded in 1994 by three parents of children with fragile X. Fragile X Syndrome is the most common inherited cause of autism and intellectual disabilities. It affects 1 in 4000 boys and 1 in 6000 girls worldwide, and one in 260 women and 1 in 800 men are carriers. Treatments for fragile X are likely to help people affected by related disorders including autism, Alzheimers, and many other brain disorders.

Your support makes it possible for us to offer high-quality patient education from top scleroderma experts, facilitate patient support groups and fund promising research.

The American Parkinson Disease Association (APDA) is the largest grassroots network dedicated to fighting Parkinson’s disease (PD) and works tirelessly to help the approximately one million with PD in the United States live life to the fullest in the face of this chronic, neurological disorder.

The Seeing Eye is a philanthropic organization whose mission is to enhance the independence, dignity and self-confidence of blind people through the use of Seeing Eye dogs.

Through education and outreach we support those affected by Lewy body dementias, and promote research for a cure.

Golden Heart Ranch (GHR) provides young adults with intellectual and development disabilities opportunities to reach their fullest potentials and enjoy meaningful, satisfying and joyful lives. We are an inclusive community where all young adults learn, work and create lifelong friendships in a supportive and caring environment.

The mission of Cure Alzheimer's Fund is to fund research with the highest probability of slowing, stopping or reversing Alzheimer's disease.

Texas Scottish Rite Hospital for Children (TSRHC) is a leading pediatric care center specializing in the treatment of orthopedic conditions, related neurological disorders and learning disorders, like dyslexia. Our mission is to improve the lives of children by providing exceptional medical care, facilitating innovative professional education programs and conducting cutting-edge research in the field of pediatric orthopedics. Since our opening in 1921, TSRHC has touched the lives of more than 225,000 children, regardless of any family's ability to pay.

HospiceCare is devoted to the concept that at the end of life every individual deseves compassion, respect, dignity and freedom from distressing symptoms. Its mission is to promote qualityOver 30 years of quality, compassionate end of life care and bereavement services. The only local not-for-profit hospice with local roots, local service and serving all communities of Berkshire County, Massachusetts. of life for the individual as well as support the loved ones before and after a patient's death.

Connecticut Hospice, America's First Hospice, honors patients and families affected by life-limiting illnesses with integrity, support, and compassion.